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We read with interest the recent publication by Méndez-Echevarría et al which compared the performance of tuberculin skin tests (TST) with a commercial interferon-γ release assay (IGRA), the QuantiFERON-TB Gold In-Tube assay, for the diagnosis of latent tuberculosis infection (LTBI) and active TB disease (TBD) in children.1 However, we believe several aspects require clarification for readers.
Consistent with previous studies evaluating TST and IGRA in children, a significant proportion (4.4%) of participants had indeterminate IGRA results and an even higher proportion (8.9%) had discordant results, which were predominately (38/41; 92.7%) TST+/IGRA−.2 Interestingly, almost all (67/68; 98.5%) children with TBD had concordantly positive …
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