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Antenatal steroid therapy and later stress responsiveness in the child

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It has been suggested that both maternal stress and antenatal administration of synthetic glucocorticoids (sGC) may cause prolonged changes in hypothalamus-pituitary-adrenal axis regulation that could affect the child in later life, increasing the risks of cardiovascular, metabolic, neuroendocrine, and psychological problems. Now a study in Germany (Nina Alexander and colleagues. J Clin Endocrinol Metab 2012;97:3538–44; see also editorial, ibid: 3457–9) has shown …

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