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169 Hospital Mortality in 2,437 Infants in the Australian, New Zealand and UK Boost II Trials of Neonatal Oxygen Saturation Targeting
  1. WO Tarnow-Mordi1,2,
  2. B Stenson3,
  3. B Darlow4,
  4. P Brocklehurst5,
  5. C Morley6,
  6. P Davis6,
  7. E Juszczak5,
  8. A King5,
  9. K Simmer7,
  10. A Kirby2,
  11. M Donoghue2,
  12. A Ghadge2,
  13. W Hague2 For the Australian, New Zealand and UK BOOST II Collaborative Study Groups
  1. 1WINNER Centre, NHMRC Clinical Trials Centre, University of Sydney
  2. 2NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
  3. 3Simpson Centre for Reproductive Health, Royal Infirmary, Edinburgh, UK
  4. 4Christchurch Women’s Hospital, University of Otago, Christchurch, New Zealand
  5. 5National Perinatal Epidemiology Unit (NPEU), University of Oxford, Oxford, UK
  6. 6Royal Womens Hospital, University of Melbourne, Melbourne, VIC
  7. 7King Edward Memorial Hospital, University of Western Australia, Perth, WA, Australia

Abstract

Background The optimal oxygen saturation (SpO2) for preterm infants is unknown. Three BOOST II trials in Australia, New Zealand and UK are comparing outcomes in infants < 28 weeks after randomisation to SpO2 targeting of 85–89% vs 91–95%, using masked oximeters.1 In interim analysis the high target increased 36 week survival in infants whose oximeter had been upgraded with new, more accurate software.2,3

Methods Pooled analysis of hospital mortality by target, overall and by old or new software.

Abstract 169 Table 1
Abstract 169 Table 2

There was no significant mortality difference between SpO2 targets overall. There was significant heterogeneity between old and new software on mortality (test for interaction p=0.006).* Using new software, targeting 91–95% increased hospital survival by 7.4% (from 76.8% to 84.2%) versus targeting 85–89% (p=0.0015).**

Conclusions Pending the primary outcome of disability free survival at 2 years it appears wise not to target 85–89%.

References

  1. Askie. BMC Pediatrics 2011; 11:6.

  2. Stenson. NEJM 2011; 364:1680–2.

  3. Johnston. Arch Dis Child Fetal Neonatal Ed. 2011; 96:429–33.

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