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321 Early Targeted Closure of Patent Ductus Arteriosus in Extreme Preterm Babies Reduces Bronchopulmonary Dysplasia
  1. P Mallya1,
  2. J Sundaram1,
  3. S Gupta1,2
  1. 1Paediatrics and Neonatal Medicine, University Hospital of North Tees, Stockton
  2. 2University of Durham, Durham, UK


Background PDA is common among very low birth weight babies. There is however growing controversy regarding treatment and clinicians are uncertain to treat or not to treat a PDA.

Objective To compare mortality and complications of prematurity in the following groups

  1. Effect of gestation; babies ≤ 28 weeks & 29–31 weeks

  2. Early (< 72 hrs) treatment vs. later symptomatic treatment of a PDA

  3. Treatment vs. no treatment of a significant PDA

Methods All babies born < 32 weeks gestation were included in this study. A total of 223 babies met the inclusion criteria from January 2009 to September 2011. Of these 22 were excluded from analysis due to incomplete data. SPSS version 17© was used for data analysis.


  1. Babies ≤ 28weeks compared to 29–31weeks gestation had significantly higher PDA (61%vs.23%; p<0.05), Bronchopulmonary dysplasia (BPD) (40%vs.12%; p<0.05), duration of respiratory support (27days vs. 9days; p<0.05) and mortality (16%vs.0%; p<0.05)

  2. Among babies with significant PDA, BPD was significantly reduced with early treatment of a PDA as compared to later symptomatic treatment (66.7%vs.82.3%; p<0.05)

  3. There was significantly higher incidence of death among babies not treated for PDA as compared to those who received treatment (29% vs. 0%; p<0.001).


  1. Babies born ≤ 28 weeks have higher burden of PDA, mortality and complications of prematurity.

  2. Treatment of PDA significantly reduces mortality.

  3. Early treatment of PDA significantly reduces BPD compared to later treatment.

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