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287 Crp Values can Differentiate between A Normal Post-Operative Response and Surgical Complications
  1. SP Sharif,
  2. SR Phelps
  1. Paediatric Surgery, The Royal London Hospital, London, UK


Aims A raised post-operative CRP is a source of great anxiety for surgeons and neonatologists. This study aims to assess the post-operative CRP response in neonates who undergo surgery in order to describe a normal physiological response to surgical trauma. This is compared to post-operative changes in neonates undergoing surgery specifically for NEC and neonates who develop surgical complications.

Methods A retrospective study was performed over a one year period (2010) analyzing consecutive neonates undergoing surgery. Daily WCC, platelet count and C-reactive protein measurements were analyzed on consecutive post-operative days in three distinct subgroups: control, surgical complications group and NEC.

Results There was a total of 81 patients (see Table 1).

Abstract 287 Table 1

As shown in Graph 1 the post-operative CRP values for the control group and complications group were significantly different throughout the 12 day time period (p=0.01, Mann-Whitney U test). The CRP values for the control group were also significantly lower than the NEC group (p=0.0001, Mann-Whitney U test).

Conclusion The post-operative CRP trend was more important than a single result. This study quantified a physiological CRP change in response to surgery in neonates. In particular, there was a significantly different CRP response in neonates who developed a post-operative complication.

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