Aim was to investigate the effects of late vs. early cord clamping on systemic circulation cerebral blood flow velocity (CBFV) in prematures infants < 1500g in a randomized trial.
Subjects 35 neonates were studied 4 hours after caesarean section. In 19 neonates (birth weight: 1140±240g; gestational age: 29.0±2 wks) the umbilical cords were clamped after 30 seconds and the infants were placed 30 cm below placenta level (LCC), and in 16 (1180±270g; 28.6±2 wks) the cords were clamped immediately (ECC).
Methods MBP (mmHg), left ventricular output (LVO, ml/kg/min), mean cerebral blood flow velocity (CBFV) in the Arteria carotis interna (ACI, m/s; Doppler), hemoglobin (Hb, g/dl), and hematocrit (Hct, %) were measured. Systemic and cerebral hemoglobin transport (HbT), systemic vascular resistance (SVR; mmHg/kg/min-1) were estimated. Statistic: *unpaared t-test.
Conclusions Late cord clamping improves blood pressure, systemic vascular resistance, hemoglobin, systemic and cerebral hemoglobin transport. The ECC group required more volume expansion in the first 24 h (ECC: 12/16, 14±7ml/kg; LCC: 6/19, 5±4ml/kg; p<0.03).