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1825 Inactivated-Trivalent Influenza Vaccination in Asthmatic Under-5 Children: A Randomized Double-Blind Placebo Trial
  1. F Fayyaz Jahani1,
  2. M Karramyyar1,
  3. E Ahmadnezhad2
  1. 1Urmia University of Medical Sciences, Urmia
  2. 2Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background There are very little evidences that influenza vaccination reduced asthma exacerbation in under-5 children and the risk of vaccination is still being discussed.

This study aimed to detect the effect of influenza vaccination on symptomatic in asthmatic under-5.

Methods A balanced RCT with 140 asthmatic day-care children with stable situation (6 to 60 months yrs), which were vaccinated with either one-dose Inactivated-trivalent Influenza vaccine or placebo was performed. They participated for only one influenza season and were followed every two weeks. We recorded when symptom scores reached a predefined severity level.

Results Exacerbation rate among vaccinated and un-vaccinated were 13% and 53%, respectively (RR=0.24, 95%CI=0.01–0.34). 48.6% of vaccinated and 768% of placebo group reported cough (RR=0.61, 95%CI=0.04–0.35). The rate of wheezing report were 20% in vaccinated and 68.6% in unvaccinated group (RR=0.25, 95%CI=0.02–2.01). The RR for dispenea was 0.36 with 95%CI that equal 0.1 to 3.65.

Conclusion In this trial we demonstrated that tolerability and efficacy of the trivalent inactivated product in under-5 children. Then this results support annual influenza vaccination in children with asthma.

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