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1716 Effects on Growth of Inhaled Corticosteroids in Asthmatic Children
  1. MBI Octavia1,
  2. BM Neamtu1,
  3. NM Leonida1,
  4. M Rodica2,
  5. C Rodica3,
  6. Z Alina4,
  7. M Ionela5,
  8. M Melania6,
  9. N Cristian7,
  10. B Radu8,
  11. O Ariela4
  1. 1Pediatric Hospital, Lucian Blaga University
  2. 2Pneumology, Pediatric Hospital Sibiu
  3. 3Pneumology, Pneumopthisiology Hospital Sibiu
  4. 4Laboratory Medicine, County Hospital
  5. 5Applied Informatics, Faculty of Science, Lucian Blaga University
  6. 6Chemistry
  7. 7Research
  8. 8Pediatric Clinic, Pediatric Hospital Sibiu, Sibiu, Romania

Abstract

Background Corticosteroids may inhibit growth hormone (GH) axis, reducing GH release, decreasing tissue expression of growth factors, inhibiting IGF-1 bioactivity, osteoblast activity, promoting bone resorption.

Objectives Evaluating adverse effects of inhaled corticosteroids used in asthmatic children on the following biological parameters: GH (two measurements), IGF-1(insulin growth factor-1), FAS (alkaline phosphatase), correlated with the presence or absence of atopy (immunoglobulin E levels).

Methods The prospective study included 74 asthmatic children, treated with inhaled corticosteroids aged between 5 and 13 years of age, divided into subgroups. Each type of inhaled glucocorticoid fluticasone, budesonide, mometasone furoate (single or in combination with long-acting bronchodilators) has been analysed for each patient. T-test, Mann-Whitney, Chi-square, binomial tests were used to ascertain the relations between average dose, the duration of treatment and the biological parameters mentioned .

Results There were found statistically significant differences (p<0.05) in:

  1. patients treated with Seretide 25/50 between the number of patients with GH values < 1ng/ml and number of patients with GH > 1ng/ml (second measurement of GH).

  2. patients treated with Symbicort 4.5/80, between the number of patients with GH values < 1ng/ml and number of patients with GH > 1ng/ml (first measurement of GH).

  3. patients treated with Seretide 50/100 for the following parameters: GH (both determinations), IgE and FAS.

Conclusions Systemic effects of fluticasone propionate and budesonide formoterol in small and medium doses were noted in the association with long-acting bronchodilators and were more extensive accordingly to the duration of treatment.

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