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1702 Increase Plasma Endothelin-1 Levels are Associated with Lung Hypertension in Low Birth Newborns with Omphalocele
  1. D Dmytriiev,
  2. O Katilov,
  3. O Mazulov,
  4. K Dmytriieva
  1. Anesthesiology and Intensive Care, Vinnitsa National Medical University, Vinnitsa, Ukraine

Abstract

Objective Increased pulmonary vascular resistance in low birth newborn with omphalocele is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns.

Methods We determined plasma (second sample) levels of endothelin-1 in 12 low birth newborns with omphalocele and 14 without omphalocele (gestational ages: 26.2±1.4 and 25.4±1.6 weeks, respectively). Blood and a second blood sample taken 18 to 40 h after birth were used for endothelin-1 determination by enzyme immunoassay.

Result Plasma levers ET-1 concentrations were higher than second sample ET-1 levels in both groups (p<0.001). There was a significant positive correlation between second sample ET-1 and SNAPPE II (r = 0.32, p=0.01). There were no correlations between plasma ET-1 levels first sample and second sample ET-1 concentrations and 5-min Apgar score < 6. Duration of mechanical ventilation had a significant positive correlation with second sample ET-1 (r = 0.46, p=0.02). Plasma lever ET-1 levels did not differ between control and omphalocele (13.0 and 14.6 pg/mL, respectively, p=0.80). Second sample ET-1 levels had significantly higher ET-1 levels than controls (1.32 and 6.04 pg/mL, respectively, p=0.001).

Conclusion Our low birth newborn with and without omphalocele had similar plasma ET-1 levels, whereas ET-1 levels were higher in omphalocele than in control newborns 18 to 40 h after birth. The increased vascular resistance in omphalocele may be related to high ET-1 levels.

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