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1653 Acute Intoxications with drug Substances in Children - A Clinical Epidemiological Study
  1. CE Singer1,
  2. P Stancu1,
  3. SC Cosoveanu1,
  4. A Botu1,
  5. S Costache2,
  6. C Cristea2
  1. 12nd Pediatric Clinic, University of Medicine and Pharmacy Craiova
  2. 22nd Pediatric Clinic, Emergency County Hospital Craiova, Craiova, Romania


Objectives Incidence of acute drug intoxications (ADI) within general pathology and various parameters (sex, social environment, age group, etiologic spectrum, clinical form, average period of hospitalization).

Material and Method A retrospective statistic study of ADI in children aged 0–16 years, admitted to 2nd Pediatric Clinic, Emergency County Hospital Craiova, over a period of 6 years (01.01.2006–31.12.2011).

Results Of the total number of 14427 admitted children, aged 0–16 years, 645 presented acute intoxications with various etiologies, among which 252 had ADI; intoxication type: accidental in 154 (61.1%), voluntary in 98 (38.9%).

Accidental ADI: sex M/F=54/100, social environment U/R=93/61, age group (years): 0–1/1–3/3–6/6–10= 27/68/33/26.

Voluntary ADI: M/F=23/75, U/R=59/39, age (years): 6–10/ 10–14/14–16= 7/37/54.

Etiologic spectrum in the studied group: AINS/antialgics in 39 (15.5%), methoclopramid 29 (11.5%), anti-epileptics 24 (9.5%), tranquilizers/sedatives 15 (5.9%), neuroleptics 9 (3.6%), para-sympathicolitics 8 (3.2%), antibiotics/antiparasitary 17 (6.7%), drugs with cardio-vascular effect 8 (3.2%), drug combinations 41 (16.3%), other drugs 12 (4.8%), unknown 50 (19.8%). Clinical forms: mild in 127 (50.4%), moderate 101 (40.1%) and severe 24 (9.5%). No deaths were registered with ADI.

Average period of hospitalization: accidental ADI 3.33±2.54 (1–9), voluntary ADI 3.28±1.24 (1–6) days.

Conclusions ADI represented 39.1% of the total number of acute intoxications; 61.1% of ADI were accidental. Most ADI were caused by AINS, methoclopramid, anti-epileptics. ADI prevailed in females, in urban children, both in voluntary and accidental ADI. The clinical forms were mostly mild.

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