Background and Aim Sweet tasting solutions and non-nutritive sucking are strong pain reducers for newborns. This study aimed to investigate effects of 30% glucose solution and non-nutritive sucking on amplitude of pain perception with pain scale, stress detector and near infrared spectroscopy (NIRS) during and after venipuncture.
Method Term newborns were randomised into two groups before venipuncture for bilirubin measurement.
Group 1 received 30% dextrose,
Group 2 received sterile water before venipuncture.
Recordings of skin conductance algesimeter (SCA, Med-Storm Innovation, Norway) from foot and NIRS (NIRO 200 Hamamatsu, Japan) from head were obtained starting 7 minutes before venipuncture until 7 minutes after. PAIN scores were obtained during and 7 minutes after procedure. Non-nutritive sucking was provided throughout the study.
Results 25 patients were included. Median PAIN scores were similar in both groups during venipuncture 5 (1–8) in Group 1, and 6 (1–10) in Group 2. Scores were decreased significantly seven minutes after procedure in both groups; as 1 (0–1) and 3 (1–3) in Group 1 and 2 respectively. In Group 1, cerebral blood volume (CBV) was increased from baseline after the procedure (p=0.008) however in Group 2 there was a decrease in CBV from baseline without statistical significance. Cerebral blood flow (CBF) was increased from baseline in both groups without statistical significance. SCA values were slightly increased from 0.23 to 0.29 in Group 1 and from 0.23 to 0.59 in Group 2.
Conclusion Nonnutritive sucking and 30% glucose attenuate pain and stress responses during venipuncture however cerebral effects are open to investigation.