Background and Aims C-Reactive Protein (CRP) is a common component of the blood panel in children being investigated for the considered diagnosis of serious bacterial infection (SBI). We aimed to correlate CRP values to SBI in a paediatric population.
Methods This is a retrospective study from 2007–2009 of all patients with CRP greater than 100mg/L. Controls were randomly selected age-matched patients with a CRP less than 100mg/L. SBI was defined as bacterial meningitis, bacteraemia, urinary tract infection, pneumonia, osteomyelitis, septic arthritis, appendicitis or abscess formation confirmed by microbiological investigations and/or supporting radiology and ultimate clinical diagnosis.
Results 570/10,191 patients had a CRP > 100mg/L. 496 patients were controls 424 patients had SBI. A significant difference between the non-SBI group (n= 642), 35±68mg/L (median±standard deviation), compared to the SBI group (n=424), 141±87mg/L, existed. The absolute and ratio risk of SBI increased consistently with rising CRP values (Table 1).
Conclusion This multi-layered risk evaluation should aid the future management of children attending the PED being investigated for SBI.
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