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1578 The Correlation Between C-Reactive Protein and Serious Bacterial Infection in a Tertiary Paediatric Emergency Department: An Observational Case-Controlled Cohort Study
  1. MJ Barrett1,2,3,
  2. J Pollock1,
  3. T Harney1,
  4. SJ Yeung1,
  5. K Laffan1,
  6. E Clarke1,
  7. S Darcy1,
  8. T Grant4,
  9. L Melody1,
  10. P Fitzpatrick1,
  11. S Cashman1,
  12. C Howard1,
  13. Z Iqbal1,
  14. F Taib1,
  15. S McCoy1,
  16. S Walsh1,
  17. R O’sullivan1,2,3
  1. 1Paediatric Emergency Research Unit, Department of Emergency Medicine, Our Lady’s Children’s Hospital Crumlin (OLCHC)
  2. 2National Children’s Research Centre, OLCHC
  3. 3Department of Paediatrics
  4. 4Public Health and Population Science, University College Dublin, Dublin, Ireland

Abstract

Background and Aims C-Reactive Protein (CRP) is a common component of the blood panel in children being investigated for the considered diagnosis of serious bacterial infection (SBI). We aimed to correlate CRP values to SBI in a paediatric population.

Methods This is a retrospective study from 2007–2009 of all patients with CRP greater than 100mg/L. Controls were randomly selected age-matched patients with a CRP less than 100mg/L. SBI was defined as bacterial meningitis, bacteraemia, urinary tract infection, pneumonia, osteomyelitis, septic arthritis, appendicitis or abscess formation confirmed by microbiological investigations and/or supporting radiology and ultimate clinical diagnosis.

Results 570/10,191 patients had a CRP > 100mg/L. 496 patients were controls 424 patients had SBI. A significant difference between the non-SBI group (n= 642), 35±68mg/L (median±standard deviation), compared to the SBI group (n=424), 141±87mg/L, existed. The absolute and ratio risk of SBI increased consistently with rising CRP values (Table 1).

Abstract 1578 Table 1

Incidence, Absolute & Ratio Risks for SBI

Conclusion This multi-layered risk evaluation should aid the future management of children attending the PED being investigated for SBI.

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