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1511 Does Nephrotoxicity Exist in Epileptic Patients on Valproate or Carbamazepine Therapy ? (A Preliminary Study)
  1. C Havali1,
  2. K Gücüyener1,
  3. N Buyan2,
  4. E Gürkaş1,
  5. E Demir1,
  6. A Serdaroğlu1
  1. 1Pediatric Neurology
  2. 2Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey


Objective The aim of the study was to investigate renal glomerular and tubular side effects of valproate and carbamazepine if exists, in children who are on these antiepileptic drugs between 6 months and two years of time.

Method A prospective study was performed on epileptic children (primary generalized and partial epilepsy) under valproate (n:30), carbamazepine (n:24) treatments and healty control group (n:26). The serum creatinine, Cystatin C levels and urinary excretion of N-acetyl-β-D-glucosaminidase levels were taken at the beginning of the study and after 6 months of therapy. Three Glomerular filtration rate formulae with creatinine, Cystatin C and combined of all of were used to determine glomerular filtration functions.

Results Serum creatinine, Cystatin C levels of patients and glomerular filtration rate values were in the normal range according to patient ages and healthy control group. However urinary N-acety-β-D-glucosaminidase/creatinine levels were higher in both groups (valproate 6.1±5) (carbamazepine 3.14±1.97) when compared to the levels of the control group (2.6±1.3) (p<0.05)Although this is a preliminary study; bearing in mind that patients on both antiepileptic drugs may have a tubulotoxicity risk; renal function test should also be checked in during the treatment of all patients with special emphasis when there is a renal or systemic disease co-existing.

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