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1500 Oxidative Stress in Iranian Epileptic Children
  1. MH Dehghan
  1. Biochemistry, Alborz University of Medical Sceinces, Karaj, Iran

Abstract

Background Lipid peroxidation is an indicator of free radical metabolism and oxidative stress in human beings and other organisms. Malondialdehyde (MDA), an end product of lipid peroxidation, is a metabolite that can be readily estimated in serum samples. Our objective in this study was to ascertain the variations in alondialdehyde (MDA) in chidren with epilepsy.

Material and Methods This study was carried out in Ardabil and Albroz provinces of Iran after obtaining clearance from the Institutional Ethics Committee. Informed consent was obtained from all the subjects. The quantitative examination of MDA was performed according to standard procedures. The ideal serum level of MDA is below 2.5 nmol/ml.

Results 90 children with confirmed epilepsy (mean age 9.3±1.5) were included in the study. MDA levels ranged from 1.5 to 3.6 nmol/ml (mean level = 2.03±0.37 nmol/ml). Eighty children (90 %) had MDA levels above the upper limit of normal. Ten patients had levels above 2.85 nmol/ml.

Conclusions This study had shown that the estimation of MDA levels in serum is a convenient method to study lipid peroxidation and thereby oxidative stress in children with epilepsy. Over half of children with epilepsy have excess oxidative stress as indicated by high levels of MDA in the serum. Correlations between MDA level and characteristics of epilepsy, AED therapy, nutritional status and other medical conditions need to be observed in a larger cohort.

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