Background To investigate whether the anomalies affecting the antioxidant defenses could start at birth and to check the decrease in antioxidant defenses in macrosomic newborns.
Material and Methods Thirty macrosomic and 30 sex-matched control newborns were recruited for a retrospective case-control study at the Maghnia Maternity Hospital of Tlemcen Department (Algeria).
Results The serum plasma ORAC, albumin, vitamin E, SOD, CAT and GSH-Px levels were significantly decreased in macrosomic than in control newborns, yet no difference was observed after adjustment for weight. Additionally, serum concentrations of malondialdehyde and xanthine oxidase were significantly higher in macrosomic than in controls before adjustment for weight. Moreover, macrosomia was significantly associated with low levels of ORAC (OR = 4.96, 95%CI 1.2–20.55), vitamin E (OR = 4.5, 95%CI 1.29–15.68), SOD (OR = 6.88, 95%CI 1.35–35.11) and CAT (OR = 5.67, 95%CI 1.37–23.46), and with high levels of MDA (OR = 10.29, 95%CI 2.02–52.36).
Conclusions Excessive weight could be a potential factor for decreased anti-oxidative capacity and increased oxidative stress.