Introduction The beneficial effects of early nutrition in preterm infants are well known. Nonetheless, almost all very low birth weight (VLBW; BW < 1500g) infants develop a protein and energy deficit in the first week of life and are growth impaired at discharged home.
We hypothesized that early parenteral lipid and high dose amino acid (AA) administration from birth onwards to VLBW infants is safe and increases growth.
Methods Inborn VLBW infants were randomized to one of three different parenteral nutritional regimens within 6hrs after birth (Figure).
Growth rates during the first 28 days of life and during total hospital stay were calculated and the incidence of common neonatal morbidities (e.g., BPD, PDA, NEC, sepsis, IVH, ROP) was recorded.
Results Growth was not significantly different between groups (Table; mean±SD). Mortality and the incidence of common neonatal morbidities were not significantly different between groups.
Conclusion Introduction of 2g lipids/(kg.d) and 3.6g AA/(kg.d) from birth onwards seems safe and does not affect the incidence of common neonatal morbidities. Growth was not improved by increasing amino acid or lipid intake in first few days of life.