Background and Aims Meconium contains large amounts of bilirubin and its retention leads to increased of enterohepatic circulation contributing to neonatal hyperbilirubinemia. The objective of study is investigate the relation of delayed passage of meconium and neonatal jaundice.
Methods This is a cross sectional study realized between August 2011 and March 2012, in rooming-in newborns at Universidade Luterana do Brasil Hospital. All the babies born at term, without hemolytic disease, no fetal anomalies, apgar greater than 7 in the fifth minute and breastfeeding only. The serum bilirubin levels (TBLs) were obtained by the apparatus Dräger Jaundice Meter JM-103®. The transcutaneous bilirubin variable was stratified according to the Bhutani nomogram. Were mensured TBLs between 24 and 59 hours of life. The protocol was approved by the institutional review board, and the parents’ written consent was obtained.
Results Groups were similar regarding demographics and clinical characteristics. Among the 670 infants studied 118(17.9%) have meconium amniotic fluid (MAF). The TBLs were lower in neonates with higher gestational age (p<0.001), MAF (p=0.007) and weight loss less than 7.5% at discharge (p=0.001). The TBLs, in neonates at ≥37 hours of life, were lower in the MAF group when compared with the group not MAF (p=0.023). There is no significant association with the classification by Bhutani nomogram and the number of evacuations at discharge (p=0,051).
Conclusions The presence of MAF showed lower TBLs. Babies with weight loss ≥7.5% have higher probability to have greater TBLs. Futher studies are needed for definite results.