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1288 Total Oxidant Levels, Total Antioxidant Levels and Paraoxonase Levels in Babies Born to Preeclamptic Mothers
  1. H Altunhan1,
  2. A Annagür2,
  3. M Konak3,
  4. S Kurban4,
  5. İ Mehmetoğlu4,
  6. R Örs3
  1. 1Abant Izzet Baysal University, Medical Faculty, Department of Neonatology, Bolu
  2. 2Selcuk University, Selcuklu Medical Faculty, Department of Neonatology
  3. 3Konya University, Meram Medical Faculty, Department of Neonatology
  4. 4Konya University, Meram Medical Faculty, Department of Clinical Biochemistry, Konya, Turkey

Abstract

Aim To investigate the oxidant-antioxidant status in babies born to preeclamptic mothers (BBPM).

Method The PON-1(Paraoxonase), TAS(Total Antioxidant Status) and TOS(Total Oxidant Status) levels were measured in the cord blood and venous blood (7day) of babies born to preeclamptic(n=31) and normotensive(N=25) mothers.

Results There was no difference between the two groups in terms of PON-1 and TOS levels in the cord blood and venous blood. However, the cord blood TAS levels were higher in BBPM (p=0.001); the TAS levels in the venous blood were higher in the control group (p=0.021). Furthermore, the cord blood PON-1 levels of babies born to severely preeclemptic mothers (n=18) were higher than those of babies born to mildly-moderately preeclamptic mothers (n=13) (p=0.042). There was no difference between cord blood TAS and TOS of babies born to severely and mildly-moderately preeclamptic mothers and the venous blood PON-1, TAS and TOS levels.

Conclusion The increased TAS level that was found in the cord blood of BBPM compared to that of the control group indicates that fetus is protected against oxidative damage caused by increased oxidative stress of the mother. Furthermore, the fact that the cord blood PON-1 level of babies born to severely preeclamptic mothers was higher than that of babies born to mildly-moderately preeclamptic mothers indicates the presence of a positive correlation between the severity of oxidative stress in the mother and the antioxidant protection of the baby. Our study is the first in the literature investigating PON-1 in BBPM.

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