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1286 Assessment of Renal and Intestinal Tissue Condition of Iugr Infant
  1. AA Akhundova1,
  2. NF Panahova2,
  3. SS Hasanov2,
  4. SA Gulieva2,
  5. NN Hajieva2
  1. 1Neonatology
  2. 2Azerbaijan Medical University, Baku, Azerbaijan

Abstract

Background As known, the main cause of IUGR is uteroplacental insuffiency accompanied by continuous hypoxia. The fetal circulatory response to hypoxia is a rapid centralization of blood flow into the brain, heart and adrenals at the expense of almost all peripheral organs, particularly the kidneys and intestines.

Aim To determine whether the IUGR has an influence on renal and intestinal function due to hypoxia-ischemia in the early neonatal period.

Material and Methods 39 preterm newborns (GA 29–36 weeks) have been studied. We compared IUGR (n=20) and non-IUGR newborns (n=19). Plasma and urine samples were taken on the 1st, 3rd and 7th day of infant’s life. KIM-1, uNGAL and plasma TFF-3 concentration were assayed by IFA method.

Results Comparing the two group levels of uNGAL, KIM-1 and TFF-3 were significantly increased in IUGR group (39.9±7.4 vs 25.8±6.5 ng/dl), (1.6±0.2 vs 0.8±0.1 ng/dl) and (38.1±1.5 vs 20.7±0.9 ng/dl) in the first three days of life. Considerable decrease in the concentration of TFF-3 was observed on the 7th day of the study (26.3±1.5 vs 28.3±2.6 ng/dl).

Conclusion Increase of KIM-1 and NGAL demonstrate high risk of hypoxic-ischemic renal injury in IUGR infants, and high level of TFF-3 reflects compensatory mechanisms in intestine in response to tissue hypoxia, but decreased level of TFF-3 in the dynamics is an evidence of failure and rapid depletion of the protective mechanisms in IUGR newborns.

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