Background and Aims To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birth weight and maternal Cr status in very low birth weight (VLBW) preterm infants.
Aims The study included 113 VLBW premature infants (< 1500 g) of ≤32 gestational week.
Results The mean level of CysC was 1.77±0.38 mg/L on day 1 and 1.61±0.37 mg/L on day 3, and the decrease was statistically significant. There was a significant correlation only between maternal Cr and first-day Cr values and negative correlations between Cr and gestational age and birth weight on third day. Creatinine was not correlated with CysC both on day 1 (r= –0.077, p=0.417) and day 3 (r=0.132, p=0.164). The reference values of Cys C at birth are [median (3p-97p)]: 1.8 mg/dl (0.8–2.2) for 24–26 weeks, 1.8 mg/dl (1.51–3.19) for 26–28 weeks, 1.8 mg/dl (0.65–2.48) for 28–30 weeks and 1.79 mg/dl (0.68–2.31) for 30–32 weeks and at 3rd days are 1.5 mg/dl (0.54–2.0) for 24–26 weeks, 1.61 mg/dl (1.1–3.4) for 26–28 weeks, 1.7 mg/dl (0.56–2.3) for 28–30 weeks and 1.6 mg/dl (0.92–2.21) for 30–32 weeks.
Conclusion CysC offer an important advantage in the measurement of renal functions independent from gestational age, birth weight and maternal Cr status in VLBW preterm infants.