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1215 Reference Values of Serum Cystatin C in Very Low Birth Weight Premature Infants
  1. G Demirel1,
  2. IH Celik1,
  3. FE Canpolat1,
  4. O Erdeve2,
  5. Z Biyikli3,
  6. U Dilmen1,4
  1. 1Neonatology
  2. 2Zekai Tahir Burak Maternity and Teaching Hospital
  3. 3Biostatistics, Ankara University
  4. 4Pediatrics, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey


Background and Aims To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birth weight and maternal Cr status in very low birth weight (VLBW) preterm infants.

Aims The study included 113 VLBW premature infants (< 1500 g) of ≤32 gestational week.

Results The mean level of CysC was 1.77±0.38 mg/L on day 1 and 1.61±0.37 mg/L on day 3, and the decrease was statistically significant. There was a significant correlation only between maternal Cr and first-day Cr values and negative correlations between Cr and gestational age and birth weight on third day. Creatinine was not correlated with CysC both on day 1 (r= –0.077, p=0.417) and day 3 (r=0.132, p=0.164). The reference values of Cys C at birth are [median (3p-97p)]: 1.8 mg/dl (0.8–2.2) for 24–26 weeks, 1.8 mg/dl (1.51–3.19) for 26–28 weeks, 1.8 mg/dl (0.65–2.48) for 28–30 weeks and 1.79 mg/dl (0.68–2.31) for 30–32 weeks and at 3rd days are 1.5 mg/dl (0.54–2.0) for 24–26 weeks, 1.61 mg/dl (1.1–3.4) for 26–28 weeks, 1.7 mg/dl (0.56–2.3) for 28–30 weeks and 1.6 mg/dl (0.92–2.21) for 30–32 weeks.

Conclusion CysC offer an important advantage in the measurement of renal functions independent from gestational age, birth weight and maternal Cr status in VLBW preterm infants.

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