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1208 New Biomarkers in Screening and Diagnosis of Vesicoureteral Reflux
  1. AA Soliman,
  2. AB Ali,
  3. MA Fathy,
  4. NT Elmeligy
  1. Pediatric, Assiut University, Assiut, Egypt

Abstract

Background Early diagnosis and treatment of vesicoureteral reflux (VUR) means prevention of 25% of cases of chronic renal impairment (CRI) which is due to reflux nephropathy.

Aim of the work This work was planned to correlate the levels of some urinary and serum biomarkers with traditional methods of diagnosis of reflux and reflux nephropathy.

Materials and Methods We evaluated urinary concentrations of IL-8 in 145 children. 105 children of them were selected from those who were diagnosed to have vesicoureteral reflux (study group). The other 40 children were apparently healthy children to serve as normal control (control group).

40 cases of the study group were randomly selected, DEMSA scan was done for them. Basic fibroblast growth factor (b-FGF) was estimated in the serum of these 40 cases.

Results Urinary IL-8 concentrations were significantly higher in study group than in control group. There was a highly significant difference in level of serum b-FGF between those with renal scarring and those without scarring.

Conclusion Urinary IL-8 can be used as a promising diagnostic marker for VUR. Also, it is appropriate to measure serum b-FGF in sera of those with reflux to determine if renal parenchymal damage (scarring) is present and of which grade.

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