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1202 Proteolytical Enzymes in Glomerulonephritis
  1. A Ciuntu1,
  2. N Revenco1,
  3. S Benesh2
  1. 1Pediatrics, USMF ‘Nicolae Testemitanu’
  2. 2Pediatrics, State Medical and Pharmaceutical University ‘N. Testemitanu’, Chisinau, Moldova

Abstract

Aim of the investigation: Study of activity of proteolytic enzymes in children with acute (AGN) and chronic (CGN) glomerylonepritis.

Materials and Methods Were investigated 50 children with acute and chronic glomerulonephritis, age from 7 to 15 years, including 30 children with AGN plus nephrotic syndrome, and 20 children with CGN, nephrotic form, period of activation and remission. Control group including 20 practically healthy children. In serum determined activity of trypsin, a-antitrypsine, and a2-macroglobuline.

Results In AGN with nephrotic syndrome, at the initial stage of the process, as well as in activation of CGN, were determined significant increasing of trypsine, a-antitrypsine, and a2-macroglobuline in comparation to control group (P<0.01). The activity of a2-macroglobuline in children with AGN plus nephrotic syndrome ant the initial stage of disease was 11.9±1.42 g/l, P<0.001, what 1.9 fold higher than in control group (6.2±0.030 g/l). In activation of CGN, nephrotic form, the activity of a2-macroglobuline was in 1.5 fold higher the indexes of control group (9.5±0.90 g/l, P<0.01).

In remission, the values of trypsin, a-antitrypsine, and a2-macroglobuline decreasing, but did not attain the basic level of control group, which suggests the persistence of activity of pathological process in kidneys.

Conclusion Determining of activity of proteolytic enzymes in serum in diagnostic criterion for determining of severity, activity of pathological process in kidneys, and determining the outcome the complications of glomerulonephritis.

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