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1145 Effects of Ibuprofen on Cerebral and Somatic Regional Tissue Oxygenation, Using Nirs in Preterm Infants with a Significant PDA
  1. K Gorman1,
  2. RM Pinnamaneni1,
  3. O Franklin1,2,
  4. A Foran1,3
  1. 1Department of Paediatrics, Rotunda Maternity Hospital
  2. 2Department of Cardiology, Our Lady’s Children’s Hospital Crumlin
  3. 3Department of Neonatology, Childrens University Hospital Temple Street, Dublin, Ireland


Introduction To investigate the impact of a haemodynamically significant patent ductus arteriosus (PDA) and its treatment with ibuprofen on regional tissue oxygenation, both cerebral and somatic (gut) using near infrared spectroscopy (NIRS).

Method Prospective observational study in the neonatal intensive care unit of Rotunda Maternity Hospital from May 2011 to April 2012. Infants < 34 weeks and < 1500g with a haemodynamically significant PDA confirmed on echocardiogram by Consultant Paediatric Cardiologist (OF) were eligible for the study. The machine used was the Somanetics INVOS system. NIRS sensors were applied to the head and liver for a minimum of 5 hours pre and 12 hours post treatment. Control patients were infants who met the above criteria but had a contraindication to ibuprofen therapy.

Results Total of 18 recordings for 15 infants, 10 in treatment group and 8 in control group. 2 infants received ibuprofen on 2 occasions. 9 male, 6 female. The mean gestational age was 26.63 (23.71–28.12) weeks and birth weight 798(550–1230)grams. The average recording was 13.46 hours pre-treatment, 39.78 hours post treatment and 39.97 hours in the control group. The median [range] cerebral regional oxygenation (cRO) pre-treatment was 68 [60–79] and post treatment was 70 [56.6–78.5]. The median [range] somatic regional oxygenation (sRO) pre-treatment was 50 [15–79] and post treatment was 54 [15–69.5]. In the control group, the median [range] cRO was 69.75 [62–78] and sRO was 40 [14–71.5].

Conclusion There was no statistically significant difference in regional tissue oxygenation (cerebral and somatic) pre and post treatment with ibuprofen.

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