Background and Aim Cardiac catheterization is an important diagnostic tool. In this study, the frequency and the factors affecting the development of thrombosis were prospectively evaluated in neonates who were subjected to diagnostic and interventional cardiac catheterization.
Method 29 patients were enrolled in this study. Blood samples were taken for complete blood count, prothrombin, activated partial thromboplastin time, INR ratio, mutation of factor V Leiden, prothrombin 20210 A, MTHFR C667 and A1298 before the procedure. 50 U/kg bolus of heparin was infused during catheterization and 20 U/kg/hour infusion of heparin was given to patients with clinically suspected thrombosis. Doppler was performed in all patients within 6 hours after catheterization.
Results Arterial catheterization in 16 cases, venous catheterization in 7 cases and both were applied in 6 cases. Arterial thrombosis in 7 patients and venous thrombosis in two patients was detected. It’s observed that infusion of 20U/kg/h heparin had no effect on the development of arterial thrombosis. On the development of arterial and venous thrombosis, patient age, gender, diagnosis, treatments received prior to catheterization, hemoglobin and platelet count, PT, aPTT and INR values and Factor V Leiden, prothrombin 20210 A, MTHFR C667, A1298 mutations were found as not impacting.
Conclusion There are no exact protocols for the prevention of thrombosis during and after catheterization. In this study, 50 unit/kg heparine bolus during catheterization and 20 unit/kg/hour heparine infusion after catheterization did not prevent the development of thrombosis. Extensive studies are needed to determine the appropriate drugs and/or doses of preventive treatments.