Aim To investigate the endothelial dysfunction in preterm newborns with birth weigth over 1500 gr which died in early neonatal period.
Methods For this purpose 30 surviving and 15 dead newborns with birth weight over1500gr were examined and divided in two groups: control group included 30 newborns, main group-15 infants died in early neonatal period. İn all infants were determined antenatal hypoxia by ultrasonography examination. In order to determine endothelial dysfunction sİCAM-1 and sVCAM-1 concentrations were detected by Uscn (Life Science Inc., USA) kits in 1st-3rd and 5th-7 th days. The Studentt-test and the Mann-Whitney test were used for comparison of parametric and non-parametric parameters.
Results On the 1st–3rd day the levels of the both adhesion molecules were higher in main group than the control group, but on the 5th–7th days of life they were significantly decreased in comparison with either control group and 1st–3rd days parameters. Adhesion molecules concentations in control group were increased in dynamic (p<0.01).
Conclusion The appointment of the level of adhesion molecules may give an opportunity to determine the endothelial dysfunction and may be predict about perinatal outcome.