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1055 Neuroimaging Prognostic Categorization in Newborns with Symptomatic Congenital Cytomegalovirus Infection (SCCI)
  1. A Alarcón1,
  2. M Martínez-Biarge2,
  3. F Cabañas2,
  4. J Quero2,
  5. A García-Alix1
  1. 1Neonatology, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues de Llobregat
  2. 2Neonatology, Hospital Universitario La Paz, Madrid, Spain

Abstract

Background and Aims In SCCI, Noyola’s neuroimaging prognostic categorization is restricted to destructive abnormalities.

Objective To ascertain the predictive ability of a classification including destructive, developmental abnormalities and white matter signal changes on MRI.

Methods Population: Patients with SCCI born between 1993–2009. Setting: La Paz Tertiary University Hospital.

Design Prospective observational. Neuroimaging (US, CT and/or MRI) findings were graded by Noyola’s and our scoring system (Table).

Abstract 1055 Table 1

Classification of neuroimaging

Blinded follow-up assessment included: neurologic examination, cerebral palsy scoring (GMFCS), cognitive evaluation (BSID-III, WPPSI-III or WISC-IV), behavioral assessment (CBCL) and evaluation of seizures, hearing or visual loss.

Results Twenty-six patients were included, 3 of which died. Mean age at follow-up was 8.7±5.3y (19m–18.0y), and 15(65%) surviving patients had moderate-severe disabilities. Our neuroimaging classification showed higher predictive ability than Noyola’s (AUC 0.94±0.04 vs 0.89±0.06, Table).

Abstract 1055 Table 2

Predictive values for adverse outcome, scores 2–3

Conclusions In SCCI, a comprehensive neuroimaging analysis including destructive and developmental abnormalities is highly predictive of neurodevelopmental outcome.

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