Background and Aims In SCCI, Noyola’s neuroimaging prognostic categorization is restricted to destructive abnormalities.
Objective To ascertain the predictive ability of a classification including destructive, developmental abnormalities and white matter signal changes on MRI.
Methods Population: Patients with SCCI born between 1993–2009. Setting: La Paz Tertiary University Hospital.
Design Prospective observational. Neuroimaging (US, CT and/or MRI) findings were graded by Noyola’s and our scoring system (Table).
Blinded follow-up assessment included: neurologic examination, cerebral palsy scoring (GMFCS), cognitive evaluation (BSID-III, WPPSI-III or WISC-IV), behavioral assessment (CBCL) and evaluation of seizures, hearing or visual loss.
Results Twenty-six patients were included, 3 of which died. Mean age at follow-up was 8.7±5.3y (19m–18.0y), and 15(65%) surviving patients had moderate-severe disabilities. Our neuroimaging classification showed higher predictive ability than Noyola’s (AUC 0.94±0.04 vs 0.89±0.06, Table).
Conclusions In SCCI, a comprehensive neuroimaging analysis including destructive and developmental abnormalities is highly predictive of neurodevelopmental outcome.