Aim and Background: Labor induction for Prepare the cervix to active phase of labor, is now one of the most common methods in the field of Obstetrics and Gynecology. This study was conducted to compare the effects of misoprostol and oxytocin in BoAli Hospital, Tehran in 2011.

Method This study was a double-blind clinical trial by recruitments of 60 primiparous women that has been referred to BoAli hospital in Tehran in 2011. Individuals were divided into two groups by random allocation. For induction of labor, misoprostol and oxytocin were prescribe in individuals who candidate for pregnancy termination by four hours intervals. For Analysis of data, t test, analysis of variance with repeated measurements, linear regression and descriptive statistics were used.

Results Mean age and standard deviation in intervention group was 24.07±3.96 and in control group equal to 24.13±3.97. Kind of treatment variable, cause of admission and hypertension history shown a significant association with increased or decreased time to achieve regular and suitable contractions for delivery (p<0.05).Results of t test in two groups of intervention and control shown that until three hours after receive Assigned treatment, there was no statistical significancy between two groups of study, But then we are clearly seeing the better impact of misoprostol drug in the intervention group (p=0.014).

Conclusion Using misoprostol in labor induction in order to reducing the Time to reach the short and effective contraction is more effective Instead of oxytocin and it can be a good alternative.