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982 Maternal Age, History of Migration and Incidence of Infantile Hypertrophic Pyloric Stenosis in Germany in 2000–2008
  1. J de Laffolie1,
  2. S Turial2,
  3. F Schier2
  1. 1General Pediatrics and Neonatology, University of Gießen, Gießen
  2. 2Department of Pediatric Surgery, University of Mainz, Mainz, Germany


Background The incidence of infantile hypertrophic pyloric stenosis (IHPS) is highly variable over time and geographic regions. A decline in IHPS incidence was recently reported in Sweden, the US, Denmark, and Scotland and in Germany.

Aim In further evaluation of our previous epidemiological data, we collected data on maternal age and history of migration in mothers from the regional administrations. We examined correlations between these factors and IHPS incidence.

Methods Data were extracted from the public report of Health (Gesundheitsberichterstattung des Bundes) and population data from federal state governments. We collected the numbers of IHPS (International Statistical Classification of Diseases and Related Health Problems, 10th revision [ICD-10], code 40.0), SIDS (ICD-10, R95), and live births (LB; male/female) in each federal state for 2000–2008. Further data were collected from federal state administrations on age of mothers at birth of first child and history of migration in % of all mothers at first birth.

Results The IHPS Incidence declined in Germany from 2000 (3.2086/1000LB [range 1.67–5.33]) to 2008 (2.0175/1000LB [1.74–3.72]; p=0.005). The recorded incidence was highly variable in different federal states and over time. Negative correlation between percentage of mothers with history of migration and maternal age at first birth on the one side and IHPS incidence in the different regions and years was significant.

Conclusion The IHPS incidence declined by about 38% nationwide. The wide variation in time and different regions is significantly correlated with maternal age and history of migration.

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