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978 Witch Drugs Choose for Sedation for Computed Tomography Imaging in Pediatric Patients, Midazolam or Propofol?
  1. Z Addou
  1. Anesthesie-Reanimation EHS Canastel, University of Oran, Oran, Algeria

Abstract

Objective To compare safety and efficacy between propofol and midazolam as sedative agents for computed tomography Imaging (CT) in children.

Material and Methods Clinical trial prospective which included 149 children who are sedated either with propofol or midazolam over 6 months period. All children below 6 years were sedated and had I-III ASA. The level of sedation, induction time, efficacy and adverse events were recorded.

Results 66 children are sedated with midazolam (mean age: 1.8years. sex ratio 0.8) and 83 children were sedated with propofol (mean age was 1.9 years; sex ratio O,6). of the 149 procedures, 76% brain, 18.1 chests, and 4.7% abdomen were scanned with mean duration for midazolam 6.8min and for propofol 7.3min and with the mean dose for midazolam 0.31mg/kg and for propofol 1.66 mg/kg. the Ramsay sedation scale for midazolam was 2–4 and for propofol was 4–5 (p<0,001). The induction time with midazolam was 3.2±3.8min and 2.9±2.5min with propofol. The completion of CT was 80% for midazolam and 95% for propofol (p<0,001). Desaturation was similar between these two drugs. The intervention needed is just the administration of supplemental oxygen. The mean duration of sedation and recovery were also similar.

Conclusion Midazolam and propofol have similar efficacy and safety for computed tomography imaging imaging in children.

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