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945 Changes of Intestinal Secretory Immunoglobulin a in Children with Rotavirus Infection
  1. I Nezgoda,
  2. O Bodnariuk
  1. Infectious Dideases in Children, Vinnitsa National Medical M.I. Pirogov Memorial University, Vinnytsya, Ukraine

Abstract

The Aim of this study was to evaluate the level of intestinal sIgA in children with rotavirus infection (RVI) depending on disease severity.

Methods Between November 2009 and February 2011, stool specimens from 85 children less than 4 years of age suffering from RVI were tested for intestinal sIgA by ELISA. 75.6% of patients were with moderate severity of disease and 23.5% - with severe course. 66 healthy children were studied as controls.

Results intestinal sIgA in patients on the 1st–2nd day of RVI was 22.6±1.05mg/l and significantly different (p<0.01) from the level of healthy children 31.8±1.35mg/l. The following dependence from disease severity was detected: intestinal sIgA in severe case-16.7±1.6mg/l which was significantly less (p<0,001) than in patients with moderate severity 24.36±1.21mg/l. Intestinal sIg A increased up to 32.74±1.53mg/l in patients with moderate severity on the 5th–6th day of disease and to 22.9±1.85mg/l in patients with severe case which were significantly different (p<0.05).

Conclusions The level of intestinal sIgA on the 1st– 2nd day of disease was less than the level of healthy children. Severe course of disease is usually present in case of low concentration of sIgA. The level of sIgA in patients with moderate severity of RVI increases up to the level of healthy children on the 5th–6th day of disease and it is significantly higher than the level of sIgA in patients with severe case at the same time (p<0.05). Thus, the low level of intestinal sIgA complicates the course of disease.

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