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939 Epidemilogic Study on Pathogenic Bacteria Causing Diarrhea in Children and Detection of Antibiotics Resistance Patterns in Hamadan, West Of Iran
  1. R Yousefimashouf1,
  2. F Eghbalian2,
  3. M Koshki3
  1. 1Department of Microbiology
  2. 2Dept. of Pediatrics
  3. 3Hamadan University of Medical Sciences, Hamadan, Iran


Background and Aim Bacterial diarrhea is very common in particular in devoloping countries and is still one of the most causes of mortalities in children. The aim of present study was to identify the most common of bacterial agents causing acute bacterial diarrhea in children under 14 years old and detection of their resistance to antibiotics.

Methods During two years, 610 samples obtained from children under 14 years old with gastroentrotitis were investigated for bacterial cultures, frequency of age, serogrouping of isolates and antibiogram patterns. Polyvalent (I, II, III, IV) and monovalant antisera were used for serogrouping of E. coli (EPEC). Antibiogram tests were also performed by gel-diffusion method of Kirby-Bauer. The data were gathered through a questionnaire and analysed using spss software.

Results Out of 610 tested samples, 155 cases (25.4%) had positve culture for intestinal pathogenic bacilli. The most common isolate was; Escherichia coli (EPEC) with 105 cases (67.8%) and the lowest isolate was Shigella with 18 cases (11.6%). The most common serogroup of E. coli was 0128 (26.6%) and the lowest serogroup was 0119 (5.7%). The most common serogroups of Salmonella were S. typhi (34.4%) and S. typhimurium. The most common serogroup of Shigella was S. sonnei (55.6%). The most effective antibiotics against bacteria were ceftriaoxne, nitrofurantoin, imipenem, amikacin and gentamycin.

Conclusions The present study showed that Escherichia coli (EPEC) and Salmonella species are predominant causes of bacterial diarrhea in children under 14 years old in this region. Most species showed high resisitance to routine antibiotics such as ampicillin, trimethoprim and chloramphenicol.

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