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909 Analysis of Newborn Screening - Born Exposed to Toxoplasmosis in Pregnancy Alcides Carneiro Hospital in Petropolis - RJ Brazil
  1. A Veiga1,
  2. MCB Soares1,
  3. R Barbosa2,
  4. R Taguti2,
  5. MM Azevedo2,
  6. CC Mouco2,
  7. EQ Veiga2,
  8. NV Moliterno2,
  9. FM Moliterno2
  1. 1Paediatrics
  2. 2Faculdade de Medicina de Petrópolis, Petrópolis, Brazil

Abstract

Background and Aims Toxoplasmosis is a cosmopolitan infection caused by Toxoplasma gondii, clinical features varying from asymptomatic infection to severe systemic manifestations. Brazil has one of the highest incidence rates of congenital toxoplasmosis in the world with estimated rates of 1:3000 live births. Knowledge of the incidence, etiology, pathogenesis, diagnosis and management of infections during pregnancy, childbirth and neonatal period is relevant because it may cause damage to the fetus and newborn, representing a public health problem worldwide. The aim of this study is evaluate the quality of neonatal screening for congenital toxoplasmosis.

Methods Retrospective study based on data collected from the medical records of 39 newborns Alcides Carneiro Hospital (HAC) in Petropolis, Rio de Janeiro, Brazil, from July 2010 to February 2012 whose mothers had seroconversion for toxoplasmosis during pregnancy. We analyzed maternal serology and treatment and clinical manifestations, laboratory and radiological newborn.

Results Forty percent of pregnant women under which seroconverted in the 3rd trimester of pregnancy, 33% at 2 and 13% in first trimester. Underwent treatment 35%, 15% and 0% respectively. There were no clinical manifestations of congenital toxoplasmosis, all showed negative IgM and IgG positive 62%. In imaging tests, 5% had changed transfontanel ultrasound (49% unknown), 1% fundoscopy losses (51% ignored), and skull radiography unchanged (23% ignored).

Conclusion Given the survey data, we conclude that there was poor adherence to native implementation of adequate prenatal care, underestimation of suspected cases with disabilities in serological screening, limited availability of laboratory diagnostic capabilities and imaging.

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