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864 Association of Fungal Infection and Increased Mortality in Children with Chronic Granulomatous Disease
  1. S Bassiri-Jahromi1,
  2. A Doostkam2
  1. 1Medical Mycology Department, Pasteur Institute, Tehran
  2. 2Shiraz University of Medical Sciences, Education Development Center, Shiraz, Iran


Background The aim of this study was to determine the incidence of fungal infections, identify the most common fungal pathogens, and determine the risk factors associated with fungal infections and mortality in children with chronic granulomatous disease (CGD).

Material and Methods All of the patients were suspected to fungal infections. The data was gathered from the medical records of all children as having CGD. The diagnostic of fungal infections were confirmed by histopathology and direct preparation, culture techniques, histopathology of surgical biopsies, and radiological examination of the affected site.

Results We evaluated twelve cases of chronic granulomatosis Patients that they are susceptible to recurrent, sever infections. Children consisted of 7 males and 5 females .The median age of patients at the time of the study was 11.66 years (3 to18). Neutrophil oxidative burst were absent (NBT=0) in all patients. Fungal infections were confirmed in five patients (41/7%) by histology and mycological methods. The most common isolated fungi in this study were Aspergillus sp. Out of 5 cases of fungal infections identified, tree were Aspergillus species, and two Fusarium species. The most common manifestations of CGD due to fungal infections were osteomyelitis (42.8%), pulmonary infections (28.6%), lymphadenopathy (14.3%) and skin involvement (14.3%) during their illness.

Conclusion Invasive fungal infections are a frequent and life-threatening complication in CGD patients. The lungs and skeletal, were the most commonly affected organ; however, lymphatic, and skin involvement have also been described. Our present study showed that fusariosisis also is a threat to CGD patients.

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