An 11 year-old boy was admitted to our hospital because of high fever, gross hematuria and pain in abdomen. He also had hypertension, nephrotic range proteinuria with renal failure, for which hemodialysis was required. Salmonella Typhi was isolated from blood culture and was diagnosed to have typhoid fever. In view of low C3 levels, renal biopsy was done, showed evidence of proliferative glomerulonephritis. On discharge, he had mildly deranged renal function with persistence of gross hematuria and proteinuria which gradually resolved over a period of one year. Renal involvement with enteric fever is noticed only in 2–3% cases. The common complications of typhoid related to the urinary tract include cystitis, pyelitis, pyelonephritis, and mild proteinuria. Few cases have been reported of acute nephritic syndrome in typhoid fever requiring renal replacement therapy. Here, we report a case of Salmonella typhi septicemia associated with acute renal failure secondary to proliferative glomeronephritis.requiring renal replacement therapy.