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829 Evaluation of Il-6 and Highly Sensitive CRP Value in CSF and Serum Children Referred to Pediatric Emergency Room
  1. A Hamedi1,
  2. H Ayatollahi2
  1. 1Pediatrics
  2. 2Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction Acute bacterial meningitis which is a pediatric emergency with high mortality and morbidity, must be diagnosed and treat promptly. Determination of some inflammatory mediators example IL-6 and hsCRP were useful in differential diagnosis of bacterial and viral meningitis.

Objectives Determination of hs CRP and IL6 in serum and CSF in children suspected meningitis.

Materials and Methods From of children that hospitalized in pediatric emergency ward and for they perfomed lumbar puncture, 1cc serum and csf of they were taken to libratory ward and have measured IL-6 with Elisa method and hsCRP with Immunoturbidometry method patients were fallowed up and Finally we compared levels of this two mediators.

Results From 81 cases, 27 cases (33/3%) were bacterial meningitis 27 cases (33/3%) were viral meningitis and 27 cases (33/3%) were Normal. IL-6 concentration in the csf and serum were significantly raised in cases of bacterial meningitis (P=0/001, P=0/01) but hsCRP concentration in the CSF and serum we not significantly raised in cases of bacterial meningitis (p=0.46, p=0.29). Mean IL-6 in serum in bacterial meningitis was (50.01) and in viral meningitis was (10.64) mean IL-6 concentration in the CSF in bacterial meningitis was (180.74) and in viral meningitis was (39.08) mean hsCRP in CSF in bacterial meningitis was (2.22) and viral meningitis was (1.29).

Conclusion The measurement of IL-6 in the CSF and serum is potentially a very useful diagnostic tool for differential diagnosis of bacterial and viral meningitis.

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