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82 Stability of Lung Function Tests Between 8 and 18 Years of Age of EPT/ELBW Survivors Compared with Term Controls
  1. LW Doyle1,2,3,
  2. A Gibson4,
  3. J Cheong1,
  4. G Roberts4,
  5. C Robertson4 The Victorian Infant Collaborative Study Group
  1. 1Royal Women’s Hospital
  2. 2University of Melbourne
  3. 3Murdoch Children’s Research Institute
  4. 4Royal Childrens Hospital Melbourne, Parkville, VIC, Australia

Abstract

Aims To determine the stability of lung function test results of extremely preterm (EPT; < 28 weeks’ gestational age) or extremely low birthweight (ELBW; birthweight < 1000g) survivors between 8 and 18 years of age compared with term controls.

Methods Eighteen-year follow-up of participants born either EPT/ELBW in 1991–92 in the state of Victoria and randomly selected term, normal birthweight controls. Lung volumes and flows, including the forced expired volume in 1 second (FEV1), forced vital capacity (FVC), the FEV1/FVC, and the forced expiratory flow (FEF25–75%) were measured at 8 and 18 years of age according to standard guidelines and results converted to Z-scores for age, height and gender.

Results Lung function data were obtained from 187/298 (63%) EPT/ELBW subjects and 147/262 (56%) controls at both 8 and 18 years. There were strong positive relationships between lung function results at 18 years with results obtained at 8 years in both groups (Table).

Abstract 82 Table 1

Data are regression coefficients (SE); *P<0.001

Relationships between 8 and 18 years were significantly stronger for EPT/ELBW subjects for both FEV1 and FEF25–75% compared with controls.

Conclusions There are strong linear relationships between lung function values at 8 and 18 years in both EPT/ELBW survivors and controls.

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