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767 Late Effects in Survivors of Infant Leukemia in Single Center
  1. S Ansari1,
  2. A Shir Ali1,
  3. S Ziaie2,
  4. P Vossough1
  1. 1Tehran University of Medical Sciences
  2. 2Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, accounting for 30%of all cancers occurring in childhood .long term sequel of treatment are now being reported. Children who survive acute lymphoblastic leukemia are at risk for leukemia-related or treatment-related complications.

Methods In this study we evaluated 66 patients with ALL have survived for more than5 years after diagnosis. Long-term squeal of treatment, such as impaired intellectual and psychomotor functioning, neuroendocrine abnormalities, impaired reproductive capacity, cardio toxicity, and second malignant neoplasm’s, are being reported.

Results of the 66 patients, 43cases were male and 23 female. Mean age was 14.59±4.36(range 10–25 years). 42 patients received chemotherapy alone, 24 patients who received chemotherapy and CNS radiation therapy. Short height 33/3%,over weight 50%, low bone density 53%, learning disabilities 6/1%, hyperthyroidism 1/5%, sexual development (pubertal delay) 7/6%, over weight are more common in children who get chemotherapy without radiotherapy. 31/8%of patients don’t have late effects. 30/3 had at least one late complication.

Conclusion These results indicate that late sequelae are common in long term survivors of infant leukemia and are often related to CRT the most common problem are short stature and over weight.

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