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750 Determining the Mean Cord Blood Immature Platelet Fraction (IPF) of Healthy Newborns
  1. A Günlemez1,
  2. M Oruç1,
  3. HM Kır2,
  4. M Çekmen2,
  5. AS Gökalp1
  1. 1Neonataology
  2. 2Biochemistry, Kocaeli University, Kocaeli, Turkey

Abstract

Thrombocytopenia is the most common hematologic abnormality in newborn infants Immature platelet fraction (IPF) shows megakaryopoetic activity. The purpose of this study is to provide non-invasive new approach to thrombocytopenic infants for further studies by determining the normal levels of the mean cord blood IPF of healthy newborns.

Methods Healthy newborns who were born at Kocaeli University in 2012, took place in this study. One ml of cord blood was obtained into EDTA tubes. Platelet counts and the mean IPF levels were studiedstudied with XE-100 (Sysmex) device. If taking blood to detect blood group is needed in 24–48 hours, IPF levels have been reworked.

Results A total of 75 infants were enrolled in this study. Mean gestational age 37.5, birth weight 3032g, platelet count 234.000/mm3, average levels of cord blood IPF 5.19%, IPF level in48th hour were found to be 4.3%.

Discussion In healthy adults, the normal values of IPF has been reported as 3.4% on average from 1.1 to 6.1%. Increased levels of IPF are shown to be related to increased platelet production; particularly in disorders related to the destruction of platelets and normal and low values of IPF are shown to be related to decreased platelet production conditions. There are limited number of researches which investigate IPF values in neonates.

Conclusion In this study we found average levels of cord blood is IPF 5.19%. Determining the right approach to thrombocytopenic patients will be possible by recognizing the normal ranges of IPF values in healthy newborns.

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