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744 Cholesterol Ester Transfer Protein Gene Polymorphism and Selected Lipids Parameters in Children from Families with History of CVS Diseases
  1. E Pac-KoZ˙uchowska,
  2. A Mroczkowska-Juchkiewicz,
  3. A Pawłowska-Kamieniak,
  4. K Kominek,
  5. D Gołyska
  1. Medical University, Lublin, Poland

Abstract

The human population especially predisposed to early development of atherosclerosis are children from families with history of cardiovascular system diseases. The aim of this study was to examine lipids parameters associated with cardiovascular diseases and polymorphisms of G279A located in the Cholesterol Ester Transfer Protein (CETP) gene.

Material/methods The study covered 30 children aged 5–6 years from families with history of cardiovascular system diseases. The children were examined physically, and nutritional status assessed. In all of the children examined, the blood concentrations of triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol, apolipoproteins (AI and B), lipoprotein(a) and polymorphisms the G279A locus of the CETP gene, were determined.

Results In children with genotype B1B1, a significantly lower % cholesterol concentration in the HDL fraction was found than in those with genotype B1B2 and B2B2. Children with genotype B1B1 were significantly shorter in stature than children with genotypes B1B2 and B2B2. Other biochemical parameters, such as levels of apolipoproteins (AI and B) and lipoprotein(a) were not significantly different between these genetic polymorphisms.

Conclusion In the future, proper early prevention based on the modification of risk factors, periodic lipid profile control, and the assay of markers of early atherosclerosis changes can reduce morbidity and mortality due to cardiovascular system diseases among children.

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