Gastrointestinal hemorrage is an emergency condition requiring immediate diagnostics. Lymphonodular hyperplasia, as a cause of bleeding from the gastrointestinal tract in children, is a rarely observed pathology of unknown etiology. The case of a 21-month-old girl is presented with massive bleeding from the lower gastrointestinal tract in the course of lymphonodular hyperplasia. Endoscopy of the upper and lower gastrointestinal tract was performed as an emergency procedure. Gastroscopic examination did not indicate any deviations from the normal. Colonoscopy showed no organic pathology of the mucosa in the terminal ileum, and the presence of blood in the small intestine was not observed. In the entire large intestine the presence of hemolyzed blood was noted and a massive lymphonodular hyperplasia on the mucosa. Histopathologic tests of the specimens taken from the large intestine confirmed normal pit patterns, mucosal edema, presence of lymph follicles, and numerous apoptic bodies in the lamina propria beneath the epithelium and in the surface epithelium.