Background and Aim Glycogenic acanthosis (GA) is usually reported as a histologic finding. The pathogenesis and aetiology of GA has not been explained definitively yet.
There are many studies about the relationship between Helicobacter pylori (H. pylori) infection and gastric or extragastric manifestations of malignant or non-malignant diseases in the literature. However, only one study deals with the association between GA and H. pylori infection.
The aim of our study was to find out whether GA is associated with H. pylori infection in children.
Methods A total of 206 children (98 female, median age 9.0 years, range 2 months-18 years), who underwent diagnostic esophagogastroduodenoscopy during a three years period, were included. GA diagnosis was based on histopathological findings seen in the distal oesophageal mucosa. The diagnosis of H. pylori infection was made if rapid urease test and histological examination of gastric biopsies obtained during endoscopy were both positive. All the findings were retrospectively examined. The Statistical Package for the Social Sciences for Windows Release 16.0 was used to analyse the statistical data.
Results Of the 206 children, 70 (34.0%) had GA. H. pylori infection was found in 72 (35%) children. No significant difference was found when the prevalence of H. pylori infection in patients with GA (24 of 70, 34.3%) was compared with that in patients without GA (48 of 136, 35.3%).
Conclusion No evidence has been found in this pediatric study to support the view that there might be an association between GA and H. pylori infection.