Objectives and study It is suggested that colonization of gastrointestinal tract by pathological microorganisms in infants may modulate local mucosal immune response and start inflammation. Disorders of the digestive system in infants may be manifested by diarrhea, blood in the stools or abdominal pain. Probiotics, which exert effect on the health and well-being of the host, may be in that situations, a potential therapeutic option. Therefore, we constructed the study to investigate the efficacy of Lactobacillus rhamnosus GG (LGG) supplementation for the eradication of pathogenic intestinal flora in infants.
Methods A randomized, double-blind, placebo controlled trial included 65 infants (31 girls and 34 boys) at age from 2-st to 20-th month. All children presented symptoms such as vomiting, diarrhea, dyspeptic stools or blood in the stools. The enteropathological bacterial flora were revealed in each cases. Infants were randomly allocated to receive Lactobacillus GG 3x109 CFU (active LGG group, n=36) or placebo (maltodextrin) (placebo group, n=29). After 14 and 28 days of oral supplementation control stool cultures were performed.
Results Compared to the placebo group, infants in LGG group had an increase in benefit of the pathological intestinal flora eradication after 14 days and 28 days of oral LGG supplementation (RR 1.31, NNT 12, RR 1.39 NNT 4) respectively.
Conclusion The use of LGG supplementation seems to be effective in the eradication of gastrointestinal colonization by pathological bacteria.