Article Text


671 Exhaled Nitric Oxide and Pulmonary Function in Children with Allergic Asthma
  1. A Omerc˘ahic’- Dizdarevic’1,
  2. S Mesihovic’-Dinarevic‘2
  1. 1Allergology, Rheumatology and Clinical Immunology
  2. 2Cardiology, Children’s Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina


Background and Aims Nitric oxide (NO) is a marker of eosinophilic inflammation in airways and can be measured in exhaled air. Fractional exhaled nitric oxide (FeNO) is elevated in allergic asthma. Children with asthma and normal spirometry (FEV1%) can have an inflammation of airways. Inhaled steroid therapy decreases FeNO levels. The aims of this study is to analyze the values of FeNO and FEV1% in children with allergic asthma (steroid naïve and undertaking inhaled steroid therapy).

Methods Thirty steroid naïve children with asthma, aged 5–15 years (<10years n=20, >10years n=10) and thirty children with asthma, undertaking inhaled steroid therapy longer than 1 month, aged 5–15 years (<10 years 18,>10 years 12), were included. Recent respiratory infections were negative in all groups. On line technique was performed in measuring FeNO using a cheiloiluminescent analyser Niox, Aerocrine-Sweden, according to ERS/ATS recommendations. Spirometry was performed by standardized procedure.

Results FeNO levels were significantly higher (Kruskal-Wallis test) in steroid naïve group(C=47.45) vs undertaking therapy group(C=11.15). Significant difference between these groups (Mann-Whitney test) was confirmed(Z=6.56; p=0,0001). 98% children in steroid naïve group had normal spirometry (FEV1%>80%). Significant difference in FEV1% (Mann-Whitney test), between steroid naïve and undertaking therapy group, was found (Z= –3.86; p=0.0001).

Conclusions Steroid naïve children with asthma had significant higher values of FeNO vs children undertaking inhaled steroid therapy. Significant difference in FEV1% was found in these two groups. In our study, steroid naive children with asthma and normal FEV1% had eosinophilic inflammation in airways.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.