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671 Exhaled Nitric Oxide and Pulmonary Function in Children with Allergic Asthma
  1. A Omerc˘ahic’- Dizdarevic’1,
  2. S Mesihovic’-Dinarevic‘2
  1. 1Allergology, Rheumatology and Clinical Immunology
  2. 2Cardiology, Children’s Hospital Sarajevo, Sarajevo, Bosnia-Herzegovina

Abstract

Background and Aims Nitric oxide (NO) is a marker of eosinophilic inflammation in airways and can be measured in exhaled air. Fractional exhaled nitric oxide (FeNO) is elevated in allergic asthma. Children with asthma and normal spirometry (FEV1%) can have an inflammation of airways. Inhaled steroid therapy decreases FeNO levels. The aims of this study is to analyze the values of FeNO and FEV1% in children with allergic asthma (steroid naïve and undertaking inhaled steroid therapy).

Methods Thirty steroid naïve children with asthma, aged 5–15 years (<10years n=20, >10years n=10) and thirty children with asthma, undertaking inhaled steroid therapy longer than 1 month, aged 5–15 years (<10 years 18,>10 years 12), were included. Recent respiratory infections were negative in all groups. On line technique was performed in measuring FeNO using a cheiloiluminescent analyser Niox, Aerocrine-Sweden, according to ERS/ATS recommendations. Spirometry was performed by standardized procedure.

Results FeNO levels were significantly higher (Kruskal-Wallis test) in steroid naïve group(C=47.45) vs undertaking therapy group(C=11.15). Significant difference between these groups (Mann-Whitney test) was confirmed(Z=6.56; p=0,0001). 98% children in steroid naïve group had normal spirometry (FEV1%>80%). Significant difference in FEV1% (Mann-Whitney test), between steroid naïve and undertaking therapy group, was found (Z= –3.86; p=0.0001).

Conclusions Steroid naïve children with asthma had significant higher values of FeNO vs children undertaking inhaled steroid therapy. Significant difference in FEV1% was found in these two groups. In our study, steroid naive children with asthma and normal FEV1% had eosinophilic inflammation in airways.

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