Background and Aim Vaspin is a visceral adipose tissue derived serin protease inhibitor which has an insulin sensitizing effect. It is correlated with insulin resistance and glucose metabolism and it improves glucose tolerance. Ou aim was to determine and compare serum vaspin and insulin concentrations in small-for-gestational age [SGA], appropriate-for-gestational age [AGA] and large- for-gestational age [LGA] infants at birth and fifth day of life.
Methods Eighty-two neonates were divided into three groups, as SGA [n=22], AGA [n=30] and LGA [n=30]. Mothers age, gestational week, mode of delivery, maternal diseases like diabetes, preeclampsia and eclampsia were recorded. Blood for vaspin, insulin and glucose was collected from cord at birth and peripheric vein on the fifth day of life.
Results At birth, there were no statistically significant difference in serum insulin concentrations between the three groups whereas cord serum vaspin concentrations were significantly higher in SGA group [χ2= 8,158 p<0.05]. Serum glucose and vaspin levels on postnatal 5th day of life had no significant difference between three groups [p<0.05]. Circulating vaspin concentrations were not associated with sex of the infant and delivery route.
Conclusion Cord vaspin levels are significantly higher in SGA neonates than AGA or LGA neonates. The fetal programming hypothesis proposes that many adulthood diseases originate through adaptation which the fetus makes when it is undernourished. High cord vaspin levels in SGA infants may be one of the adaptation for increased risk for adult metabolic diseases.