Objective The aims of the study were to determine the effect of preeclampsia on bronchopulmonary dysplasia (BPD) development in preterm infants and to investigate the possible association between BPD severity and preeclampsia.
Methods The study group involved preterm infants (≤32 gestational week) born to a preeclamptic mother with no co-existing medical condition, whereas the comparison group involved preterm infants born to a normotensive mother. BPD was defined as requirement for supplemental oxygen for the first 28 day of life. It was classified as mild, moderate and severe BPD. The demographics and clinical data of the infants were recorded.
Results There were 117 and 215 premature infants in the study and control groups, respectively. The incidence of BPD in preterm infants in the study group (38.5%) was significantly higher than the control group (19.5%). The frequency of moderate and severe BPD were significantly higher in the study group. In logistic regression model, preeclampsia was found to be predictive of BPD.
Conclusions Preeclampsia was found to be an important risk factor for BPD development in preterm infants. The incidence of both moderate and severe BPD was significantly higher in preeclamptic mother infants. These findings might be associated with altered angiogenesis in the preeclamptic mother which might be shared with the fetus.