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601 Does Bronchopulmonary Dysplasia Relate to Redox Status in Infants Less than 29 Weeks of Gestational Age?
  1. ISI Mohamed1,
  2. JC Lavoie2,3
  1. 1Pediatrics - Neonatology
  2. 2Pediatrics- Neonatology
  3. 3Centre de Recherche, Universite de Montreal - CHU Sainte-Justine, Montréal, QC, Canada

Abstract

Background Glutathione is the key molecule in detoxification of peroxides leading to an oxidized glutathione redox status (GRS). We hypothesizes that GRS plays an important role in the etiology of bronchopulmonary dysplasia (BPD).

Objective To test the relation between GRS at 6–7 days of life as well as at 36 weeks of corrected age and BPD. To identifty perinatal factors affecting GRS.

Design/methods Whole blood GRS was measured at 6–7 days of life and at 36 weeks of corrected age (CA) in 51 infants less than 29 weeks of gestational age (GA). Perinatal clinical data that may affect the GRS were colleted. The GRS was calcualted using concentration of GSH and GSSG according to the Nernst equation (Schafer & Buettner, 2001).

Results Infants in our cohort had gestational age of 26±1 weeks with birth weight of 847±166 gm. Significant relation between GRS and BPD was confirmed with less risk of BPD in infants with most reduced GRS (day 6–7) and higher risk of BPD for infants with most oxidized GRS at 36 weeks CA.

Abstract 601 Figure 1

Relation between GRS and BPD

GA and BW were signifcantly related to GRS.

Abstract 601 Table 1

Different perinatal factors effect on GSR

Conclusions There is a significant relation between GRS 6–7 days of life as well as at 36 weeks CA and BPD outcome in infants less than 29 weeks of GA. The significant impact of both GA and BW on GRS at 6–7 days of life is explained by the glutathione level that is correlated with gestational age.

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