Background and Aims Thalassemia is a genetic and crucial disease. Approximately 240 million peoples are suffering from this disease. Every year 10 million children are suffering from this disease.Hb-E dieases is available in south east Asia, north east India and Bangladesh. Originalally Hb-E disease is 5 times more than Beta Thalassemia in Bangladesh.

Method The outbreak of this disease is not calculated at this moment but carrier is 15 million. We are collected experimental data from 3 hundred voluntiers in our center. They have not family history of Thalassemia. In that experimental data Beta Thalassemia carrier 2.33% and Hb-E Carrier 10%. If we are experiment among the people who have history of Thalassemia, this disease is increased no doubt. This disease have actually no curable treatment except BoneMarrow tranplantation. Treatment cost is excessive and unbearable. Only time to time Blood transfusion and costly drug is given for the increasing of life span. Treatment cost of every 30kg child need 4 lac taka every year. If 2 bag blood need every patient in every month, 1 lac 20 thousand bag blood will be need every month in Bangladesh.

Result Bonemarrow tranplantation is the only curable treatment of this disease. About 3 million to 10 million taka need for this treatment. Above this situation we learn that prevention is only way to reduce this diseases. Screening system NESTROFT is available in our center. Only 10 taka need. Some cases DNA analysis will be need.

Conclusion Antenatal diagnosis is important and available in our center. If the foetus suffering from this disease legal termination of pregnancy should be need. This way we can free from the disease.