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489 Interleukin Phenotype in Patients with Pfapa
  1. SI Iurian1,
  2. L Dobrota1,
  3. S Iurian2,
  4. ML Neamtu1,
  5. L Bera3,
  6. A Rosenberg4
  1. 1Research Department, Pediatric Clinic, Lucian Blaga University
  2. 2Clinical Laboratory, Pediatric Hospital
  3. 3Lucian Blaga University
  4. 4Pediatric Hospital, Sibiu, Romania

Abstract

Background PFAPA is a chronic condition including recurrent fever episodes, aphthous stomatitis, pharyngitis, adenitis. According to a previous study, even between febrile attacks, there is increasing of pro-inflammatory mediators.

Aims

  1. To evaluate serum interleukin phenotype between febril episode in PFAPA patients from our clinic;

  2. To establish correlation between C reactive protein (CRP) and pro-inflammatory interleukins: tumor necrosis factor-alpha (TNFα), interleukin-8 (IL-8);

  3. To evaluate link between CRP and anti-inflammatory interleukins: interleukin-10 (IL-10);

  4. To identify a sensitive biological marker to estimate PFAPA evolution.

Methods Authors analyzed 2 groups: “PFAPA group” represented by 6 patients and “control group” containing 4 no-PFAPA patients. Inclusion citeria: patients up to 10 years of age that fulfilled PFAPA diagnosis criteria; patients between febrile attacks; negative procalcitonin (PCT) blood value in order to exclude bacterial infections for study patients. Exclusion criteria: patients during febrile attacks. Both groups patients were tested for serum levels of PCT, CRP, IL-8, TNFα, IL-10. Data was statistically analyzed using independent “t” test.

Results Both group patients have normal serum levels for interleukins 8/10 and high TNFα values. Mean value for TNFα was 11.26 pg/ml in PFAPA group and 13.2 pg/ml in no-PFAPA group. Regarding CRP values, mean value for PFAPA patients was 19.72 (range between 2.4–95) as compare to 5.04 in no-PFAPA patients.

Conclusions TNFα, IL-8, IL-10 aren’t useful to appreciate PFAPA evolution pattern. CRP remains a sensitive marker for disease activity in PFAPA patients, even out of fever attacks. Our study didn’t confirm previous study data.

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