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480 Successful Blood Sample Salvaging from Preterm Infants: Maximising Research Opportunities, Minimising Parental and Infant Interventions
  1. J Berrington1,2,
  2. E Turnbull2,
  3. S Turner3,
  4. S Douglas3,
  5. N Embleton1,2
  1. 1Institute of Health and Society, Newcastle University
  2. 2Neonatal Medicine
  3. 3Biochemistry, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

Abstract

Backround and aims Research improves care for preterm infants but taking blood may be inappropriate/ethically challenging, and limited by patient size. We aimed to ‘salvage’ residual blood after routine testing, and sought parental perspectives.

Methods We gave parents a single information leaflet and asked permission to collect non-invasive or ‘un-used’ samples to support a portfolio of research studies: stool/breast milk (gut microbiome), serum (cytokine), and DNA from residual cell pellet (epigenetic). We also sought consent for sample sharing with other approved studies. Parents could decline specific aspects. Serum/cell salvage was stored prior to analysis.

Results 99% of parents participated: 92 recruits provided 527 salvaged blood samples supporting two additional studies to date.

Abstract 480 Table 1

Conclusions Parents wanted to participate in research with non-invasive sampling/salvage of waste. This provided valuable samples over extensive time periods. This could be used in other vulnerable groups. Bio-banking of such valuable samples may provide important opportunities for future research, avoid additional invasive sampling, and be time efficient.

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