Objective To evaluate the efficacy of resistin in the diagnosis of sepsis and to compare with C-reactive protein (CRP) in preterm infants.
Study Design Totally 80 preterm infants were prospectively included in the study. Blood samples were collected within the first hour of life, on first and third days of sepsis for basal resistin, basal CRP, CRP-1, CRP-3, resistin-1 and resistin-3 levels. Septic patients were divided into two groups as Gr-negative and Gr-positive sepsis group.
Results Basal resistin and CRP levels were 14.0 (4.7–31.1) ng/ml and 0.5 (0–23) mg/dL. Culture-proven sepsis was diagnosed in 20 infants. Resistin-1 and resistin-3 were significantly higher than basal resistin levels (p<0.01) and positively correlated with CRP. The area under curve values for CRP and resistin were 0.714 and 0.984, respectively (p=0.039). Resistin-1 and resistin-3 levels were significantly higher in Gr-negative sepsis group than Gr-positive (p<0.001).
Conclusion We showed that resistin had an efficacy superior to that of CRP in the diagnosis of sepsis in preterm infants. Resistin can be used as an early marker for sepsis in premature infants. Further studies are needed in larger groups to better understand the role of resistin to determine cut-off values for Gram-negative and positive sepsis.